Chapter 23 WAN Optimization, Web Cache, Explicit Proxy, and WCCP : Configuring WAN optimization : WAN optimization and user and device identity policies, load balancing and traffic shaping
  
WAN optimization and user and device identity policies, load balancing and traffic shaping
Please note the following about WAN optimization and firewall policies:
WAN optimization is not compatible with firewall load balancing.
WAN optimization is compatible with source and destination NAT options in firewall policies (including firewall virtual IPs). If a virtual IP is added to a policy the traffic that exits the WAN optimization tunnel has its destination address changed to the virtual IPs mapped to IP address and port.
WAN optimization is compatible with user identity-based and device identity security policies. If a session is allowed after authentication or device identification the session can be optimized.