Just like other components of the FortiGate, there is the option for different Proxy Option profiles so that you can be very granular in your control of the workings of the FortiGate. In the case of the Proxy Option profiles the thing that you will want to focus on is the matching up of the correct profile to a firewall policy that is using the appropriate protocols. If you are creating a Proxy Option profile that is designed for policies that control SMTP traffic into your network you only want to configure the settings that apply to SMTP. You do not need or want to configure the HTTP components.