Chapter 15 Unified Threat Management for FortiOS 5.0 : Security Profiles overview : Content inspection and filtering : AntiVirus : AntiVirus recommendations
  
AntiVirus recommendations
Enable antivirus scanning at the network edge for all services.
Use FortiClient endpoint antivirus scanning for protection against threats that get into your network.
Subscribe to FortiGuard AntiVirus Updates and configure your FortiGate unit to receive push updates. This will ensure you receive new antivirus signatures as soon as they are available.
Enable the Extended Virus Database if your FortiGate unit supports it.
Examine antivirus logs periodically. Take particular notice of repeated detections. For example, repeated virus detection in SMTP traffic could indicate a system on your network is infected and is attempting to contact other systems to spread the infection using a mass mailer.
The builtin-patterns file filter list contains nearly 20 file patterns. Many of the represented files can be executed or opened with a double-click. If any of these file patterns are not received as a part of your normal traffic, blocking them may help protect your network. This also saves resources since files blocked in this way do not need to be scanned for viruses.
To conserve system resources, avoid scanning email messages twice. Scan messages as they enter and leave your network or when clients send and retrieve them, rather than both.